Innate Lymphoid Cells
Innate lymphoid cells (ILCs) were discovered about a decade ago and are the most recently identified population of immune cells that belong to the lymphoid lineage. They represent a distinct arm of the innate immune system that can directly communicate with a wide variety of haematopoietic and non-haematopoietic cells to mediate host defence, inflammation and metabolic homeostasis in multiple tissues.
Unlike adaptive T and B lymphocytes, they lack pattern-recognition receptors and somatically rearranged antigen receptors and therefore cannot respond to pathogenic insult in an antigen-specific manner. They are ubiquitously distributed throughout the body and enriched at mucosal and barrier surfaces, serving as the first line of defense against microorganisms.
Although present in relatively low numbers, the selective distribution of ILCs within tissues seems to confer a remarkable ability
to regulate multiple physiological processes throughout the body.
Understanding the dysregulation of ILCs in the context of infectious, metabolic, and chronic inflammatory conditions in humans might provide therapeutic solutions in the treatment of diverse autoimmune inflammatory diseases and cancers.
ILC’s are divided into 3 main Groups: ILC 1, ILC2 and ILC3. Modulating the activity of these cells is the focus of Innate Lymphoid Cell Therapeutics (ILC) Ltd.
Key Cells, Cytokine and Chemokines
Further Information & Downloads
Overview of Hybrid 1
A summary of the immune mechanisms understood to be involved in Atopic Dermatitis and Psoriasis, and describes how the HYBRID 1 molecule is active against many facets of the 2 diseases simultaneously.
Overview of Hybrid 2
A novel, synthetic Alpha-Interferon-associated molecule, with high activity, for the treatment of cancer.
Strictly necessary cookies guarantee functions without which this website would not function as intended. As a result these cookies cannot be deactivated. These cookies are used exclusively by this website and are therefore first party cookies. This means that all information stored in the cookies will be returned to this website.
Functional cookies enable this website to provide you with certain functions and to store information already provided (such as registered name or language selection) in order to offer you improved and more personalized functions.
Performance cookies gather information on how a web page is used. We use them to better understand how our web pages are used in order to improve their appeal, content and functionality.
Marketing / Third Party Cookies originate from external advertising companies (among others) and are used to gather information about the websites visited by you, in order to e.g. create targeted advertising for you.