About Psoriasis

    • Psoriasis is a chronic inflammatory disease of the skin affecting about 1-5% of the world over 100 million people. Anyone can get Psoriasis and tends to appear between the ages of 15 and 35.Psoriasis causes patches of thick red sore skin with silvery scales that itch or feel sore. It can be mild and localised to the hands or severe and cover large areas of the body.
    • There is currently no cure for Psoriasis but treatments can slow down the growth of skin cells or relieve pain, itching and discomfort.  Biological drugs have been introduced in recent years. These drugs have been shown to have “Drug Survival Times” of 30 months to 60 months in patients before they loose efficacy.
    • Psoriasis appears to originate from the body loosing control over an Innate Immune response designed to protect the skin from fungal infections. ILC Therapeutics™ have developed and patented a number of synthetic peptides shown to modulate the key cellular players in this inflammatory immune response. These peptides may be able  to significantly down regulate the Psoriatic immune response.

    Neutrophil & ILC3 Effects

     

    ILC Therapeutics™ is developing the first topical biologic for the treatment of psoriasis to address the  unmet clinical need for 80% of sufferers; 

    Its pre-clinical research has demonstrated that the  molecule ILCT-1001 targets and inhibits the clinically-validated IL-17A,F and TNF-α pathways, with further suppressive effects on other key cytokines/chemokines implicated in psoriasis

    In-vitro studies show that ILCT-1001 acts directly on human keratinocytes (skin cells) at low concentrations to suppress production of the chemokines responsible for the skin damage – this makes this molecule ideal for use as a topical agent 

    Despite being a biologic, its low molecular weight (17 kilodaltons) allows the molecule to penetrate the dermis and permit a therapeutic effect from the surface through to sub-dermal

    ILCT-1001 is a recombinant molecule which demonstrates measurable effects at very low concentrations. As it is derived from a natural molecule, it is therefore likely to be safe and well tolerated 

    In-vitro toxicology assays support this safety assertion: it has displayed no cytotoxicity up to the highest concentrations (5x106 IU/ml)